904686-27-7 Usage
Uses
Used in Chemical Research:
Ethanone, 1-[4-(5-pyrimidinyloxy)phenyl]is used as a research compound for the development of new organic compounds and the study of chemical reactions involving aryl-phenylketones. Its unique structure allows for the exploration of various synthetic pathways and the investigation of its reactivity with other chemical entities.
Used in Pharmaceutical Development:
Ethanone, 1-[4-(5-pyrimidinyloxy)phenyl]is used as a key intermediate in the synthesis of pharmaceutical compounds. Its potential pharmacological properties have been investigated, making it a promising candidate for the development of new drugs with therapeutic applications.
Used in Medicinal Chemistry:
Ethanone, 1-[4-(5-pyrimidinyloxy)phenyl]is used as a building block in the design and synthesis of novel bioactive molecules. Its structure and functional groups provide opportunities for the development of compounds with specific biological activities, such as enzyme inhibition, receptor modulation, or other pharmacological effects.
Used in Drug Synthesis:
Ethanone, 1-[4-(5-pyrimidinyloxy)phenyl]is used as a starting material or intermediate in the synthesis of various drug candidates. Its versatile structure allows for the incorporation of different functional groups and the formation of diverse chemical entities with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 904686-27-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,4,6,8 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 904686-27:
(8*9)+(7*0)+(6*4)+(5*6)+(4*8)+(3*6)+(2*2)+(1*7)=187
187 % 10 = 7
So 904686-27-7 is a valid CAS Registry Number.
904686-27-7Relevant academic research and scientific papers
Novel pyrrolyl 2-aminopyridines as potent and selective human β-secretase (BACE1) inhibitors
Malamas, Michael S.,Barnes, Keith,Hui, Yu,Johnson, Matthew,Lovering, Frank,Condon, Jeff,Fobare, William,Solvibile, William,Turner, Jim,Hu, Yun,Manas, Eric S.,Fan, Kristi,Olland, Andrea,Chopra, Rajiv,Bard, Jonathan,Pangalos, Menelas N.,Reinhart, Peter,Robichaud, Albert J.
scheme or table, p. 2068 - 2073 (2010/06/19)
The proteolytic enzyme β-secretase (BACE1) plays a central role in the synthesis of the pathogenic β-amyloid in Alzheimer's disease. Recently, we reported small molecule acylguanidines as potent BACE1 inhibitors. However, many of these acylguanidines have a high polar surface area (e.g. as measured by the topological polar surface area or TPSA), which is unfavorable for crossing the blood-brain barrier. Herein, we describe the identification of the 2-aminopyridine moiety as a bioisosteric replacement of the acylguanidine moiety, which resulted in inhibitors with lower TPSA values and superior brain penetration. X-ray crystallographic studies indicated that the 2-aminopyridine moiety interacts directly with the catalytic aspartic acids Asp32 and Asp228 via a hydrogen-bonding network.
Amino-pyridines as inhibitors of beta-secretase
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Page/Page column 28-29, (2008/06/13)
The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
