9047-55-6Relevant academic research and scientific papers
Disulfide bond formation in S-Acetamidomethyl cysteine-containing peptides by the combination of silver trifluoromethanesulfonate and dimethylsulfoxide / aqueous HCI
Tamamura, Hirokazu,Otaka, Akira,Nakamura, Junko,Okubo, Kaori,Koide, Takaki,Ikeda, Kyoko,Fujii, Nobutaka
, p. 4931 - 4934 (2007/10/02)
S-Acetamidomethyl (Acm) cysteine was found to be converted quantitatively to cystine by deprotection of the Acm group with silver trifluoromethanesulfonate (AgOTf) followed by dimethylsulfoxide (DMSO) / aqueous hydrochloric acid (HCl) treatment. No significant side reactions were observed with oxidation-sensitive amino acids such as Met, Tyr, and Trp under these reaction conditions. This method has been applied successfully to the syntheses of oxytocin and a Trp-containing peptide, urotensin II.
