90474-14-9

Usage

InChI:InChI=1/C8H10O4/c1-4-2-5(7(9)10)6(3-4)8(11)12/h5-6H,1-3H2,(H,9,10)(H,11,12)

Upstream product

• 343956-49-0 4-Methylene-cyclopentane-1,2-dicarboxylic acid diethyl ester 
• 6261-04-7 2,3,4-tris(ethoxycarbonyl)cyclopentanone 
• 1703-61-3 rac-4-oxocyclopentane-1,2-dicarboxylic acid 
• 914637-96-0 diethyl 4-oxo-1,2-cyclopentanedicarboxylate 
• 4373-15-3 1,2,3,4-butanetetracarboxylic acid tetraethyl ester 
• 4534-68-3 1,2,3,4-butanetetracarboxylic acid 

Downstream Products

• 198022-60-5 (+)-(1S,2R)-4-methylene-2-[(2E)-3-phenyl-2-propenyloxycarbonyl]cyclopentanecarboxylic acid 
• 198022-61-6 (+)-(1R,2S)-4-methylene-2-[(2E)-3-phenyl-2-propenyloxycarbonyl]cyclopentanecarboxylic acid 

Relevant academic research and scientific papers

Novel antifungal β-amino acids: Synthesis and activity against Candida albicans

A series of novel β-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. β-Amino acid 21 (BAY 10-8888/PLD-118) revealed the most favourable activity-tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.

DIANION OF 1,2-BIS(4',4'-DIMETHYL-2'-OXAZOLIN-2'-YL)ETHANE VERSATILE SYNTHETIC REAGENT FOR ANNULATION

Treatment of 1,2-bis(4',4'-dimethyl-2'-oxazolin-2'-yl)ethane with butyllithium produced the corresponding dianion, which on exposure with 1,ω-dihalides gives cyclic derivatives.The same dianion react with the β-bromoesters to yield substituted cyclopentanones.