90475-55-1Relevant academic research and scientific papers
Diastereoisomeric quaternary morphinium salts: Synthesis, stereochemistry and analgesic properties
Iorio,Disciullo,Mazzeo Farina,Frigeni
, p. 11 - 16 (2007/10/02)
Diastereoisomeric quaternary morphinium salts were prepared by alkylation of morphine with alkyl halides or by alkylation of N-alkylnormorphines with methyl iodide. Nitrogen configuration of diastereoisomeric pairs was assigned by means of 1H NMR chemical shifts of corresponding N-methyl protons. These compounds were evaluated for analgesic activity by the guinea pig ileum assay and by the hot-plate test after icv administration in mice. The correlation between N-substituent orientation and narcotic agonist/antagonist activity is discussed.
