904896-12-4

Usage

General Description

1-Piperazinecarboxylic acid, 4-(4-formyl-3-nitrophenyl)-, 1,1-dimethylethyl ester is a chemical compound with the molecular formula C15H20N4O6. It is an ester of the carboxylic acid 1-piperazinecarboxylic acid with the aldehyde 4-formyl-3-nitrophenyl. 1-Piperazinecarboxylic acid, 4-(4-formyl-3-nitrophenyl)-, 1,1-dimethylethyl ester is commonly used in organic synthesis and medicinal chemistry for the preparation of various pharmaceutical and agrochemical molecules. It is also used as an intermediate in the production of dyes, pigments, and other fine chemicals. Its structural properties and reactivity make it a versatile building block for the synthesis of diverse classes of organic molecules with potential biological activities.

Upstream product

• 2923-96-8 4-fluoro-2-nitrobenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1403501-08-5 tert-butyl 4-(4-(3-cyano-5-(ethoxycarbonyl)-6-(4-methoxyphenyl)-2-(methylthio)-1,4-dihydropyridine-4-yl)-3-nitrophenyl)piperazine-1-carboxylate 
• 1403501-09-6 tert-butyl 4-(4-(3-cyano-5-(ethoxycarbonyl)-6-(4-methoxyphenyl)-2-(methylthio)pyridin-4-yl)-3-nitrophenyl) piperazine-1-carboxylate 
• 1403501-11-0 tert-butyl 4-(1-cyano-4-(4-methoxyphenyl)-2-(methylthio)-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridin-8-yl)piperazine-1-carboxylate 
• 1403501-13-2 tert-butyl 4-(1-amino-5-(4-methoxyphenyl)-6-oxo-6,7-dihydro-3H-benzo[f]pyrazolo[3,4-c][2,7]-naphthyridin-9-yl)piperazine-1-carboxylate 
• 1403501-39-2 tert-butyl 4-(1-cyano-5-ethoxy-4-(4-methoxyphenyl)-2-(methylthio)benzo[c][2,7]naphthyridin-8-yl)piperazine-1-carboxylate 
• 1403501-24-5 tert-butyl 4-(1-cyano-6-ethyl-4-(4-methoxyphenyl)-2-(methylthio)-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridin-8-yl)piperazine-1-carboxylate 
• 1403501-38-1 1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide 
• 1403501-07-4 tert-butyl 4-(4-(3-amino-2-cyano-3-thioxoprop-1-enyl)-3-nitrophenyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT

The present invention relates to compounds of following general formula (I): and to the pharmaceutically acceptable salts of same, the tautomers of same, the stereoisomers or mixture of stereoisomers in any proportions of same, such as a mixture of enantiomers, notably a racemic mixture, as well as to methods for preparing same and uses of same, notably as an antineoplastic agent.

IGF-1R INHIBITOR

The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents -NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, -C(=O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.