904923-95-1

Basic information

• Product Name: 1-Chloro-6-fluoronaphthalene
• Synonyms: 1-Chloro-6-fluoronaphthalene
• CAS NO: 904923-95-1
• Molecular Formula: C10H6ClF
• Molecular Weight: 180.6060432
• Mol File: 904923-95-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Chloro-6-fluoronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-6-fluoronaphthalene(904923-95-1)
• EPA Substance Registry System: 1-Chloro-6-fluoronaphthalene(904923-95-1)

Safety Data

• Hazardous Substances Data: 904923-95-1(Hazardous Substances Data)

Usage

Type of compound

Aromatic hydrocarbon

Substituents

Chloro and fluoro groups attached to a naphthalene ring

Common uses

a. Intermediate in the synthesis of dyes, pharmaceuticals, and agrochemicals
b. Building block in the production of organic electronic materials
c. Reagent in organic chemistry reactions

Hazardous nature

Classified as a hazardous chemical

Safety precautions

Proper handling and usage with safety measures in place to avoid harmful exposure

Upstream product

• 13997-72-3 1-allyl-2-hydroxy-5-fluorobenzene 
• 371-41-5 4-Fluorophenol 
• 62078-78-8 6-Fluoro-1-amino-naphthalene 

Relevant articles and documents

Cobalt-Catalyzed Enantioselective C–H Arylation of Indoles

Atropoisomeric (hetero)biaryls are scaffolds with increasing importance in the pharmaceutical and agrochemical industries. Although it is the most obvious disconnection to construct such compounds, the direct enantioselective C–H arylation through the concomitant induction of the chiral information remains extremely challenging and uncommon. Herein, the unprecedented earth-abundant 3d-metal-catalyzed atroposelective direct arylation is reported, furnishing rare atropoisomeric C2-arylated indoles. Kinetic studies and DFT computation revealed an uncommon mechanism for this asymmetric transformation, with the oxidative addition being the rate- and enantio-determining step. Excellent stereoselectivities were reached (up to 96% ee), while using an unusual N-heterocyclic carbene ligand bearing an essential remote substituent. Attractive dispersion interactions along with positive C–H-π interactions exerted by the ligand were identified as key factors to guarantee the excellent enantioselection.

A remarkably simple and efficient benzannulation reaction

(Chemical Equation Presented) On a short fuse: Although fused aromatic rings are common structural motifs in natural products, there are relatively few direct methods for the preparation of such systems from acyclic precursors. An atom-transfer radical cyclization carried out under microwave (MW) irradiation has now been developed which gives rapid access to functionalized aromatic compounds from readily available starting materials (see scheme).

DIHYDROIMIDAZOTHIAZOLE DERIVATIVES

Compounds of formula (I): or pharmaceutically acceptable salts thereof, exhibit 5-HT1A agonism in addition to noradrenaline reuptake inhibition and optionally also 5-HT reuptake inhibition are useful for the treatment of obesity.