904961-22-4

Basic information

• Product Name: Acetamide, N-[3-[2-(4-hydroxyphenoxy)-5-thiazolyl]-1-methyl-2-propynyl]-
• CAS NO: 904961-22-4
• Molecular Formula: C15H14N2O3S
• Molecular Weight: 302.354
• Mol File: 904961-22-4.mol

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[3-[2-(4-hydroxyphenoxy)-5-thiazolyl]-1-methyl-2-propynyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[3-[2-(4-hydroxyphenoxy)-5-thiazolyl]-1-methyl-2-propynyl]-(904961-22-4)
• EPA Substance Registry System: Acetamide, N-[3-[2-(4-hydroxyphenoxy)-5-thiazolyl]-1-methyl-2-propynyl]-(904961-22-4)

Safety Data

• Hazardous Substances Data: 904961-22-4(Hazardous Substances Data)

Upstream product

• 123-31-9 hydroquinone 
• 904961-21-3 4-(5-bromothiazol-2-yloxy)phenol 
• 42105-25-9 N-(1-methyl-prop-2-ynyl)acetamide 

Downstream Products

• 916795-86-3 {4-[5-(3-acetylamino-but-1-ynyl)-thiazol-2-yloxy]-phenoxy}-acetic acid 
• 916795-85-2 {4-[5-(3-acetylamino-but-1-ynyl)-thiazol-2-yloxy]-phenoxy}-acetic acid methyl ester 

Relevant articles and documents

Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity

Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the l

Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.