904962-27-2

Upstream product

• 903886-90-8 4-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]but-3-yn-2-ol 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 831-82-3 4-Phenoxyphenol 
• 904962-37-4 5-[3-(tert-butyl-dimethyl-silanyloxy)-but-1-ynyl]-2-(4-phenoxy-phenoxy)-thiazole 
• 903886-77-1 5-iodo-2-(4-phenoxyphenoxy)thiazole 
• 903886-76-0 2-(4-phenoxyphenoxy)thiazole 

Relevant academic research and scientific papers

The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

The structure-activity relationship study focused on the polar region of the HTS hit A-80040 (1) producing several series of potent and selective ACC2 inhibitors. The SAR suggests a compact lipophilic pocket that does not tolerate polar and ionic groups.

Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.