904962-32-9

Basic information

• Product Name: Thiazole, 4-bromo-2-[4-(1-methylethoxy)phenoxy]-
• CAS NO: 904962-32-9
• Molecular Formula: C12H12BrNO2S
• Molecular Weight: 314.203
• Mol File: 904962-32-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Thiazole, 4-bromo-2-[4-(1-methylethoxy)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 4-bromo-2-[4-(1-methylethoxy)phenoxy]-(904962-32-9)
• EPA Substance Registry System: Thiazole, 4-bromo-2-[4-(1-methylethoxy)phenoxy]-(904962-32-9)

Safety Data

• Hazardous Substances Data: 904962-32-9(Hazardous Substances Data)

Upstream product

• 7495-77-4 4-isopropoxyphenol 
• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 123-31-9 hydroquinone 

Relevant articles and documents

Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy) thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors

A structurally novel acetyl-CoA carboxylase (ACC) inhibitor is identified from high-throughput screening. A preliminary structure-activity relationship study led to the discovery of potent dual ACC1/ACC2 and ACC2 selective inhibitors against human recombinant ACC1 and ACC2. Selective ACC2 inhibitors exhibited IC50 1000-fold selectivity against ACC1. (S)-Enantiomer 9p exhibited high ACC2 activity and lowered muscle malonyl-CoA dose-dependently in acute rodent studies, whereas (R)-enantiomer 9o was weak and had no effect on the malonyl-CoA level.