905272-80-2Relevant academic research and scientific papers
Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis
Zhao, Xiaohu,Xu, Haiyan,Huang, Xiaolei,Zhou, Jianrong Steve
, p. 292 - 296 (2019)
Asymmetric reductive amination of poorly nucleophilic sulfonamides was realized in the presence of nickel catalysts and titanium alkoxide. A wide range of ketones, including enolizable ketones and some biaryl ones, were converted into sulfonamides in excellent enantiomeric excess. The cyclization of sulfamates and intermolecular reductive amination of a diarylphosphinamide were also successful. Formic acid was used as a safe and economic surrogate of high-pressure hydrogen gas.
Preparation method of atinib intermediate (by machine translation)
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Paragraph 0038-0039, (2020/08/06)
The preparation method comprises the following steps: taking -1 - fluoroacetophenone as a starting raw material, sequentially subjecting the intermediate (S) 4 - (-1 - fluorophenyl) 2 - [-1 - (piperaz -5 -yl) pyrimid 4 -1 -yl] ethylamine through an addition reaction and a hydrolysis reaction under the catalysis of organic metal through an imidization reaction and an organic metal catalysis reaction and a hydrolysis 4 - reaction.1 - 2 -1 -5 . The preparation method is simple in process, mild in condition, safe and environment-friendly, and provides a new way for industrial production of atinib. (by machine translation)
Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines
Mou, Chengli,Wu, Jichang,Huang, Zhijian,Sun, Jun,Jin, Zhichao,Chi, Yonggui Robin
supporting information, p. 13359 - 13362 (2017/12/26)
A carbene-catalyzed LUMO activation of α,β-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction.
