905273-34-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2,3-bis-bromoMethyl-pyridine serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Bromo-2,3-bis-bromoMethyl-pyridine is employed as an intermediate for the production of pesticides and other agrochemicals. Its chemical properties allow for the creation of effective compounds that can protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
5-Bromo-2,3-bis-bromoMethyl-pyridine is utilized in organic synthesis for the preparation of a wide range of organic compounds. Its versatility and reactivity make it a valuable component in the synthesis of various organic molecules with diverse applications in different industries.

Upstream product

• 583-61-9 2,3-Lutidine 
• 1356330-71-6 5-bromo-2,3-bis(hydroxymethyl)pyridine 
• 521980-82-5 5-bromopyridine-2,3-dicarboxylic acid dimethyl ester 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 27063-90-7 3-bromo-5,6-dimethylpyridine 

Downstream Products

• 905273-36-1 3-bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 
• 1613148-38-1 N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine 
• 1613148-44-9 (6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)boronic acid 
• 1613148-45-0 3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine 
• 1613148-39-2 3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine 
• 1393546-06-9 3-bromo-6-(tert-butoxycarbonyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 

Relevant academic research and scientific papers

Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery

Using X-ray crystallographic screening, fragments 4 and 6 were identified as inhibitors of hematopoietic prostaglandin D2 synthase (H-PGDS). Both fragments induced a small protein movement in the X-ray crystal structure relative to the apo structure, where the highly polar nature of the ligand complemented the induced protein conformation. The manuscript describes the fragment optimisation of 4 and 6 followed by fragment growth to lead molecule 10. This showed favourable physicochemical properties and evidence of oral activity in blocking PGD2 generation in vivo.

PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES

The present invention relates to a class of TrkA inhibitors and an application thereof in the preparation of a drug for the treatment of diseases associated with TrkA. The present invention specifically discloses compounds represented by formula (I) and f

PIPERIDINYL AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4 and R5 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and co

Substituted ring compound and its method and use thereof

The invention provides a substituted cyclic compound as well as a use method and application thereof. The compound is a compound as shown in a formula (I) or stereoisomers, stereomers, tautomers, nitric oxides, solvates, metabolites and pharmaceutically acceptable salts or prodrugs of the compound as shown in the formula (I). The invention further provides a medicament composition containing the compound. The compound and the medicament composition are capable of regulating the activity of protein kinase in a biological sample body and are used for protecting, treating or relieving proliferative diseases of patients. The formula (I) is as shown in the specification.

BETA-LACTAMASE INHIBITORS

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted alkynyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.