905294-97-5Relevant academic research and scientific papers
BACE-1 inhibition by a series of ψ[CH2NH] reduced amide isosteres
Coburn, Craig A.,Stachel, Shawn J.,Jones, Kristen G.,Steele, Thomas G.,Rush, Diane M.,DiMuzio, Jillian,Pietrak, Beth L.,Lai, Ming-Tain,Huang, Qian,Lineberger, Janet,Jin, Lixia,Munshi, Sanjeev,Katharine Holloway,Espeseth, Amy,Simon, Adam,Hazuda, Daria,Graham, Samuel L.,Vacca, Joseph P.
, p. 3635 - 3638 (2006)
A series of β-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitors containing a ψ(CH2NH) reduced amide bond were synthesized. Incorporation of this reduced amide isostere as a non-cleavable peptide surrogate afforded inhibitors possessing low nanomolar potencies in both an enzymatic and cell-based assay.
