905302-06-9

Upstream product

• 905302-05-8 N-benzyl 2,2-difluoro-3,3-dimethylpent-4-enamide 
• 344295-08-5 methyl 2,2-difluoro-3,3-dimethylpent-4-enoate 
• 905302-04-7 2,2-difluoro-3,3-dimethylpent-4-enoic acid 
• 905302-03-6 3-methylbut-2-enyl 2-chloro-2,2-difluoroacetate 
• 556-82-1 3-methyl-2-buten-1-ol 
• 100-46-9 benzylamine 

Downstream Products

• 905302-09-2 (1-benzyl-4,4-difluoro-3,3-dimethylpyrrolidin-2-yl)methanol 
• 905302-08-1 1-benzyl-3,3-difluoro-4,4-dimethyl-5-methylenepyrrolidin-2-one 

Relevant academic research and scientific papers

Fluorination-free synthesis of a 4,4-difluoro-3,3-dimethylproline derivative

A Claisen rearrangement/iodolactamization sequence starting from commercially available trifluoroacetaldehyde methyl hemiacetal, followed by a classical chemical resolution, provided enantiomerically pure 4,4-difluoro-3,3-dimethylproline (S)-1. No hazardo