905307-53-1Relevant academic research and scientific papers
Kinetic resolution of racemic 2-hydroxyamides using a diphenylacetyl component as an acyl source and a chiral acyl-transfer catalyst
Murata, Takatsugu,Kawanishi, Tatsuya,Sekiguchi, Akihiro,Ishikawa, Ryo,Ono, Keisuke,Nakata, Kenya,Shiina, Isamu
, (2018/09/26)
Various optically active 2-hydroxyamide derivatives are produced based on the kinetic resolution of racemic 2-hydroxyamides with a diphenylacetyl component and (R)-benzotetramisole ((R)-BTM), a chiral acyl-transfer catalyst, via asymmetric esterification and acylation. It was revealed that a tertiary amide can be used with this novel protocol to achieve high selectivity (22 examples; s-value reaching over 250). The resulting chiral compounds could be transformed into other useful structures while maintaining their chirality.
