90537-01-2

Upstream product

• 186581-53-3 diazomethane 
• 62551-42-2 2-dibromomethyl-benzoic acid 
• 89-71-4 2-Methyl-benzoic acid methyl ester 

Downstream Products

• 4122-56-9 methyl o-formylbenzoate 
• 1432518-91-6 methyl 2-[bis(phenylsulfanyl)methyl]benzoate 
• 1432519-24-8 (S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate 
• 1432519-22-6 (5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one 
• 1432519-25-9 (S)-{2-[bis(benzenesulfonyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate 
• 1432518-90-5 2-{2-[bis(phenylsulfanyl)methyl]phenyl}acetaldehyde 
• 1443988-19-9 C₂₂H₂₀OS₂ 
• 1432518-88-1 2-[bis(phenylsulfanyl)methyl]benzaldehyde 
• 1432518-92-7 {2-[bis(phenylsulfanyl)methyl]phenyl}methanol 
• 136054-95-0 Methanesulfonic acid 2-[2-(3-methoxy-1-oxo-1H-inden-2-yl)-phenyl]-ethyl ester 
• 136054-96-1 2-(ω-bromoethylphenyl)-3-methoxyindenone 
• 136054-94-9 2-(ω-hydroxyethylphenyl)-3-methoxyindenone 
• 136054-93-8 3-methoxy-2-(2-styryl)indenone 
• 35106-82-2 2-vinylbenzylalcohol 

Relevant academic research and scientific papers

Asymmetric synthesis of carbocycles: Use of intramolecular conjugate displacement

Intramolecular conjugate displacement (ICD), the process illustrated in eqn (1), has been applied to the Morita-Baylis-Hillman adducts formed from (5S)-5-(l-menthyloxy)-2(5H)-furanone and aldehydes that are substituted in the γ- or δ-position by geminal phenylthio groups. When the initial Morita-Baylis-Hillman alcohols are acetylated and oxidized to geminal sulfones, deprotonation causes ring closure by ICD (2.5→2.6). Hydrogenation, DIBAL-H reduction and desulfonylation releases an optically pure carbocycle. The Royal Society of Chemistry 2013.

Synthesis of spirononane system present in fredericamycin A

Two different approaches for the construction of spirononane system present in fredericamycin A (1) have been reported.In the first approach (2-(β-haloethyl)phenyl)-indane-1,3-dione-methyl enolate (17) was subjected to trimethylsilyliodide reaction

Palladium(II)-mediated Synthesis of Spirononane System Present in Fredericamycin A

A convenient approach for the construction of spirononane system present in fredericamycin A (1) has been achieved utilizing Pd(II) acetate mediated cyclisation of the 1,3-indanedione intermediate (10).