90537-62-5Relevant academic research and scientific papers
Synthesis and bioactivities evaluation of novel vv-pyridylpyrazole derivatives with 1,2,3-triazole and quinazolin-4(3H)-one substructures
Wei, Wei,Zhu, Liangliang,Zhou, Yunyun,Li, Zhengming
, p. 1453 - 1462 (2018/08/29)
Two series of JV-pyridylpyrazole derivatives containing 1,2,3-triazole and quinazolin-4(3H)-one substructures were designed and synthesized. In total, 18 novel compounds were prepared, and all compounds were characterized by 1H NMR, 13C NMR and elemental
Quinazolin-4-one derivatives
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Page/Page column 28-29, (2010/11/24)
A medicament having an inhibitory activity against hematopoietic prostaglandin D2 synthase, which comprises as an active ingredient a compound represented by the following general formula (I) or a salt thereof: wherein X represents a group represented by the formula —N═C(R5)— or the formula —NH—CH(R5)—, R1, R2, R3, and R4 represent a hydrogen atom, a halogen atom, a C1 to C6 alkyl group, or a hydroxy group, R5 represents a C1 to C6 alkyl group or a C6 to C10 aryl group, and R represents an amino group.
Fused pyrimidines. Synthesis of new derivatives of potential diuretic activity
Eisa,El-Ashmawy,Tayel,Abo El-Magd,El-Kashef
, p. 585 - 590 (2007/10/03)
Certain derivatives of quinazoline and its bioisostere pyridopyrimidine carrying important structural features that contribute to diuretic activity, such as sulfonamido, morpholino and chlorophenyl, were prepared as potential diuretic agents. Likewise, some tricyclic 1,2,4-triazolo[3,4-b]quinazolins and pyrido[3,2-d][1,2,4]triazolo[4,3-a] pyrimidines with the same features were reported. Nine compounds were tested for the diuretic activity in rats and the results showed that the active compounds is 7-chloro-2-methyl-3-phthalimido-4(3H)-quinazoline.
