905439-46-5

Upstream product

• 884603-56-9 (5-bromo-pyrimidin-2-yl)-(2-morpholin-4-yl-ethyl)-amine 
• 134690-40-7 3-ethynyl-4-methylaniline 

Downstream Products

• 905439-44-3 (4-methyl-3-[2-(2-morpholin-4-yl-ethylamino)-pyrimidin-5-ylethynyl]-phenyl)-carbamic acid phenyl ester 

Relevant academic research and scientific papers

Aminopyrimidine Derivatives With Tie2 Inhibiting Activity

The invention relates to a compound of the Formula I or salt thereof wherein Rx, Ry, Rx, R5, R6, A, B, L, n and m are as defined in the description. The invention also relates to pharmaceutical compositions of said compounds, the use of said compounds as medicaments and in the production of an anti-angiogenic effect in a warm blooded animal. The invention also relates to processes for the preparation of said compounds.

PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY

The invention relates to a compound of the Formula (I) or salt thereof wherein Rx, Ry, Rz, R5, R6, A, B, L, n and m are as defined in the description. The invention also relates to pharmaceutical compositions of said compounds, the use of said compounds as medicaments and in the production of an anti-angiogenic effect in a warm blooded animal. The invention also relates to processes for the preparation of said compounds.