905451-66-3Relevant academic research and scientific papers
Total synthesis of cryptophycin analogues via a scaffold approach
McCubbin, J. Adam,Maddess, Matthew L.,Lautens, Mark
, p. 2993 - 2996 (2006)
Allylation of in situ generated β,γ-unsaturated aldehydes affords rapid access to vinyl halide analogues of fragment A of the cryptophycins. Three scaffolds are prepared in gram quantities by a ring-closing metathesis approach. Derivatization via a variety of cross-coupling protocols is possible, which affords novel analogues of these potent antimitotic agents.
