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1-(5-Bromo-4-fluoro-2-hydroxyphenyl)ethanone is a chemical compound with the molecular formula C8H7BrFO2. It is a derivative of acetophenone, containing a bromine and fluorine atom on the phenyl ring, as well as a hydroxyl group attached to the second carbon of the ethanone group.
Used in Pharmaceutical Industry:
1-(5-Bromo-4-fluoro-2-hydroxyphenyl)ethanone is used as an intermediate for the synthesis of various pharmaceuticals and agrochemicals. It possesses potential biological activities and is utilized in the development of new drugs.
Used in Organic Synthesis:
1-(5-Bromo-4-fluoro-2-hydroxyphenyl)ethanone is used as a synthetic intermediate in the preparation of various organic compounds.
Safety and Handling:
It is important to handle 1-(5-Bromo-4-fluoro-2-hydroxyphenyl)ethanone with care due to its potential hazards, and safety and handling information should be followed.

905454-90-2

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905454-90-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 905454-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,5,4,5 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 905454-90:
(8*9)+(7*0)+(6*5)+(5*4)+(4*5)+(3*4)+(2*9)+(1*0)=172
172 % 10 = 2
So 905454-90-2 is a valid CAS Registry Number.

905454-90-2Upstream product

905454-90-2Relevant academic research and scientific papers

Hydroxylated nebivolol metabolites

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Sheet 16, (2010/11/25)

Hydroxylated nebivolol metabolites increase NO release from human endothelial cell preparations in a concentration dependent fashion following acute administration. In addition, hydroxylated nebivolol metabolites, including but not limited to 4-hydroxy-6,6′difluoro-, 4-hydroxy-5-phenol-6,6′difluoro-, and 4-hydroxy-8-pheno-6,6′difluoro-, have the ability to increase the capacity for NO release in human endothelial cells following chronic administration. This invention provides hydroxylated nebivolol metabolites and compositions comprising nebivolol and/or at least one hydroxylated metabolite of nebivolol and/or at least one additional compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof. In addition, this invention provides methods of treating and/or preventing vascular diseases by administering at least one hydroxylated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease. Also, this invention is directed to the treatment and/or prevention of migraine headaches administering at least one hydroxylated metabolite of nebivolol. This invention may also be used in conjunction with or as a single treatment of metabolic syndrome disorders.

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