9055-20-3

Usage

Uses

Used in Medical Research:
EC 1.11.1.10 is used as a useful alternative to lactoperoxidase for 131I ion labeling studies, enabling researchers to track and study the behavior of iodine in biological systems.
Used in Protein Modification:
EC 1.11.1.10 is used for bromination of proteins, allowing for the attachment of bromine atoms to specific amino acid residues, which can be useful for studying protein structure and function.
Used in Macromolecule Labeling:
EC 1.11.1.10 is used for 36Cl labeling of macromolecules in long-term isolation procedures, providing a means to track and study the behavior of macromolecules over extended periods.
Used in Pharmaceutical Industry:
EC 1.11.1.10 is used as a therapeutic agent for the treatment of various diseases, including cancer, due to its ability to generate reactive oxygen species and induce apoptosis in cancer cells.
Used in Food Industry:
EC 1.11.1.10 is used as a natural preservative in the food industry, as it can inactivate spoilage microorganisms and extend the shelf life of dairy products and other perishable foods.

Biochem/physiol Actions

Chloroperoxidase (CPO) is a 42,000 Da extracellular heme glycoenzyme containing ferriprotoporphyrin IX as the prosthetic group. CPO is secreted from fungus and exhibits a broad spectrum of chemical reactivities. It is a peroxide-dependent chlorinating enzyme. It also catalyzes peroxidase-, catalase- and cytochrome P450-type reactions of dehydrogenation, H2O2 decomposition and oxygen insertion, respectively. The enzyme has magnetic and spectroscopic properties similar to that of cyctochrome P-450. CPO from the fungus Caldariomyces fumago has the capacity to chlorinate aromatic hydrocarbons, including polycyclic aromatic hydrocarbons (PAHs).