905584-27-2Relevant articles and documents
HIV-1 integrase inhibition of biscoumarin analogues
Chang-Xiao,Mouscadet, Jean-Francois,Chiang, Chih-Chia,Tsai, Hou-Jen,Hsu, Ling-Yih
, p. 682 - 686 (2007/10/03)
Nineteen biscoumarins bearing free and modified hydroxyl substituents at benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among these biscoumarins, thirteen were found to be active molecules against HIV-1 integrase (HIV-1 IN). The structure-activity relationship of the nineteen compounds on HIV IN may be useful for the design of potent therapeutic agents.