905589-40-4

Upstream product

• 382138-92-3 (S)-5-methyl-6-oxo-1-trimethylsilyl-hept-1-yne 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 905589-22-2 (2S,9S,12S,13S)-12,15-Bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-9-methyl-2,13-bis-triethylsilanyloxy-pentadec-5-yne-4,10-dione 
• 905589-33-5 (5S,8S,9S)-8,11-Bis-benzyloxy-5-methyl-9-triethylsilanyloxy-1-trimethylsilanyl-undec-1-yn-6-one 
• 905589-54-0 (5S,8S,9S)-8,11-Bis-benzyloxy-9-(4-methoxy-benzyloxy)-5-methyl-1-trimethylsilanyl-undec-1-yn-6-one 
• 905589-35-7 (5S,8S,9S)-8,11-Bis-benzyloxy-1-iodo-5-methyl-9-triethylsilanyloxy-undec-1-yn-6-one 
• 905589-30-2 (5S,8S,9S)-11-Benzyloxy-8-hydroxy-9-(4-methoxy-benzyloxy)-5-methyl-1-trimethylsilanyl-undec-1-yn-6-one 
• 905589-55-1 (5S,8S,9S)-8,11-Bis-benzyloxy-9-hydroxy-5-methyl-1-trimethylsilanyl-undec-1-yn-6-one 
• 905589-53-9 (S)-trimethyl(5-methyl-6-(trimethylsilyloxy)hept-6-en-1-ynyl)silane 
• 905589-37-9 (2S,9S,12S,13S)-12,15-Bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2,13-dihydroxy-9-methyl-pentadec-5-yne-4,10-dione 
• 905589-56-2 (5S,6S,9S,16S)-6-benzyloxy-5-(2-(benzyloxy)ethyl)-3,3-diethyl-14-hydroxy-9,20,20-trimethyl-19,19-diphenyl-16-triethylsilyloxy-4,18-dioxa-3,19-disilahenicos-12-yn-8-one 

Downstream Products

• 1054667-82-1 (2S,3S,5R,7R,9S,15S)-3-Benzyloxy-2-(2-benzyloxy-ethyl)-9-(tert-butyl-diphenyl-silanyloxymethyl)-15-methyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadecan-11-one 

Relevant academic research and scientific papers

Synthesis of the trioxadispiroketal domain of spirastrellolide B

Assembly of the trioxadispiroketal domain of the naturally occurring protein serine/threonine phosphatase inhibitor spirastrellolide B via a staged double intramolecular hetero-Michael addition is detailed.

Synthesis of the spirastrellolide A trioxadispiroketal

The core trioxadispiroketal system representing C26-C40 of spirastrellolide A was assembled using a sequenced double-intramolecular hetero-Michael addition process.