90562-75-7

Usage

Chemical compound

2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-,hydrazone(9CI)

Derivative of

Benzimidazol-2-one

Structure

Heterocyclic compound with a benzene ring fused to an imidazole ring

Potential applications

Medicinal chemistry, scaffold for designing pharmaceutical agents

Promising candidate for

Research into potential therapeutic uses

Potential uses

Drug for treatment of various diseases and conditions

Further studies needed

To fully understand potential and develop applications in medicine

Upstream product

• 58533-15-6 2-chloro-1-ethyl-1H-benzo[d]imidazole 
• 4857-06-1 2-chloro-1H-benzoimidazole 

Downstream Products

• 379226-77-4 1-(2-Pyridyl)-1-ethanone-1-(1-ethyl-1H-benzo[d]imidazol-2-yl)hydrazone 
• 1219829-40-9 C₁₁H₁₀N₄O₂ 

Relevant academic research and scientific papers

A Pyridyl-Linked Benzimidazolyl Tautomer Facilitates Prodigious H+/Cl-Symport through a Cooperative Protonation and Chloride Ion Recognition

We report two pyridyl-linked benzimidazolyl hydrazones as HCl cotransporters that are 5 and 2 times superior to prodigiosin, a natural product whose transport efficiency has never been routed by synthetic molecules. These hydrazones provide a suitable HCl binding site through a cooperative protonation and chloride ion recognition. HCl transport by the most active compound induces lysosome deacidification. Viability assays confirmed that the compounds induce cytotoxicity toward human breast cancer MCF-7 cells but are relatively nontoxic toward noncancerous HEK293T cells.

Synthesis and biological evaluation of [1,2,4]triazino[4,3-a] benzimidazole acetic acid derivatives as selective aldose reductase inhibitors

The acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole (TBI) were synthesized and tested in vitro and in vivo as selective aldose reductase (ALR2) inhibitors. Compound PS11 showed highest inhibitory activity (IC50) 0.32 μM and was f