90568-07-3

Usage

Uses

Cyclopropylmethyl-d2 Alcohol (CAS# 90568-07-3) is a useful isotopically labeled research compound.

Upstream product

• 1759-53-1 cyclopropanecarboxylic acid 
• 2868-37-3 methyl cyclopropylcarboxylate 

Relevant academic research and scientific papers

Cyclopropylmethyl/cyclobutyl rearrangements on surfaces: Evidence for transient cation formation near O-covered Mo(110)

Rearrangement reactions of C4-alkoxides on O-covered Mo(110) have been studied using temperature-programmed reaction spectroscopy and reflection-absorption infrared spectroscopy. Cyclobutoxide on Mo(110), prepared from the corresponding alcohol or bromide, is described for the first time in detail. Several reaction mechanisms are considered for the ring-opening rearrangement of cyclopropylmethoxide during high-temperature annealing. In light of compelling new data, previous results are reinterpreted to support the formation of transient cations near O-covered Mo(110). For the first time, we present strong evidence for clean, heterolytic bond cleavage reactions over a metal surface. Our revised reactivity model is based on spectroscopic and reactivity data that show the rearrangement of cyclopropylmethyl groups to cyclobutyl groups and vice versa. Selectively deuterated 1,1-D 2-cyclopropylmethanol was studied as a test of mechanism and as a probe for the lifetime of reactive intermediates. Isotopic scrambling observed for this substrate is consistent with the formation of a relatively long-lived carbocation during rearrangement. The intermediacy of transient cations is further invoked to explain the rearrangements that are now recognized to occur as alkyl bromides are transformed into alkoxides on Mo(110)-(1 x 6)-O. The observed ring expansion/contraction reactions are characteristic of a cationic process; carbon-centered radicals are not known to rearrange in this manner. However, in none of the cases discussed could contributions from radical pathways be completely ruled out. Our results are compared to analogous reactions in the vapor and solution phases. General trends governing rearrangement mechanisms on Mo(110) are presented with respect to metal-surface coverage, heteroatom incorporation, and temperature. Trends are discussed in the context of heterogeneous hydrocarbon oxidation.

3-formamido-4-hydroxyl naltrexone deuterated derivative, preparation method thereof and application of 3-formamido-4-hydroxyl naltrexone deuterated derivative in medicine

The invention relates to a 3-formamido-4-hydroxyl naltrexone deuterated derivative, a preparation method thereof and application of the 3-formamido-4-hydroxyl naltrexone deuterated derivative in medicine. In particular, the present invention relates to a 3-formamido-4-hydroxynaltrexone deuterated derivative represented by a general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and application of the 3-formamido-4-hydroxyl naltrexone deuterated derivative as an opioid receptor modulator in the treatment of cough, diarrhea, drug dependence, gastrointestinal tract diseases, allergic bowel syndrome, obesity, respiratory depression, convulsion, pain, allergy, pruritus and other diseases, and central nervous system diseases or/and mental diseases and other related diseases, wherein each substituent in the general formula (I) is as defined in the specification.

HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS

Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

Rearrangements concerted with fragmentation of cyclopropylmethoxychlorocarbene and cyclobutoxychlorocarbene in hydrocarbon solvents and Ar matrices

Fragmentations of cyclopropylmethoxychlorocarbene (6) and cyclobutoxychlorocarbene (10) lead to rearrangments that afford mixtures of cyclopropylmethyl chloride (7), cyclobutyl chloride (8), and 3-butenyl chloride (9). Isotopic substitution studies show that these rearrangments are accompanied by partial exchange of the methylene groups within 6 and 10. Surprisingly, these processes that are typical of carbocations persist in hydrocarbon solvents such as pentane and cyclohexane-d12. Quantum chemical calculations reveal that the cis-conformers of the incipient oxychlorocarbenes C 4H7OCCl decay to C4H7Cl + CO via transient hydrogen bonded C4H7 σ+...Clσ- complexes which possess significant ion pair character, even in the gas phase or in nonpolar solvents. In contrast to benzyloxychlorocarbene, no free radicals are formed upon generation or photolysis of 6 or 10 in Ar matrixes, although acid chlorides (the recombination products of these radical pairs) are observed. The IR spectra obtained in these experiments show the presence of several conformers of the two C4H7OCCl.