905710-82-9

Usage

Chemical class

Benzene derivatives

Structure

Contains a bromine and a fluorine atom on the benzene ring, and a 2-(methoxymethoxy)ethyl group attached to the benzene ring

Applications

Commonly used in organic synthesis and medicinal chemistry

Intermediate

May be used as an intermediate for the production of pharmaceuticals or agrochemicals

Building block

Presence of bromine and fluorine atoms makes it a useful building block for the synthesis of complex organic molecules

Versatility

Methoxymethoxyethyl group adds versatility for potential biological activity

Field of use

Has various potential applications in the field of chemistry and drug development

Upstream product

• 866029-28-9 2-(2-bromo-5-fluorophenyl)ethan-1-ol 
• 107-30-2 chloromethyl methyl ether 
• 905710-81-8 2-(2-bromo-5-fluorophenyl)acetaldehyde 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 

Relevant academic research and scientific papers

Benzoxaborole-1-alcohol compound and preparation method and application thereof

The invention belongs to the field of bactericides, and particularly relates to a benzoxaborole-1-alcohol compound and a preparation method and application thereof. The benzoxaborole-1-alcohol compound has good bactericidal activity, can effectively control tomato early blight, wheat scab, rice sheath blight disease, strawberry gray mold, apple blotch, cucumber anthracnose and other crop diseases,can produce excellent antibacterial effects at low concentration, and shows good selectivity. The compound is used as a leucyl-tRNA synthetase inhibitor, the evolution difference of aminoacyl-tRNA synthetase of germs and eukaryotes is utilized, and the compound has very high safety to non-target organisms while killing the germs and can be used as a bactericide in agriculture.

Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use

Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

Compounds for the Treatment of Periodontal Disease

Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

Boron-containing small molecules

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.