905838-89-3Relevant academic research and scientific papers
Thiophene substituted acylguanidines as BACE1 inhibitors
Fobare, William F.,Solvibile, William R.,Robichaud, Albert J.,Malamas, Michael S.,Manas, Eric,Turner, Jim,Hu, Yun,Wagner, Erik,Chopra, Rajiv,Cowling, Rebecca,Jin, Guixan,Bard, Jonathan
, p. 5353 - 5356 (2008/09/21)
A series of thiophene-substituted acylguanidines were designed from a pyrrole substituted acylguanidine HTS lead. This template allowed a greater flexibility, through differential Suzuki couplings, to explore the binding site of BACE1 and to enhance the i
Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators
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Page/Page column 10, (2008/06/13)
The present invention provides a substituted thienyl or furyl acylguanidine compound of formula I The present invention also provides methods for the inhibition of β-secretase (BACE) and for the treatment of β-amyloid deposits and neurofibrillary tangles.
