905846-76-6

Basic information

• Product Name: C₅₄H₈₈N₄O₁₃S
• Synonyms: C₅₄H₈₈N₄O₁₃S
• CAS NO: 905846-76-6
• Molecular Weight: 1033.38
• Mol File: 905846-76-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₄H₈₈N₄O₁₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₄H₈₈N₄O₁₃S(905846-76-6)
• EPA Substance Registry System: C₅₄H₈₈N₄O₁₃S(905846-76-6)

Safety Data

• Hazardous Substances Data: 905846-76-6(Hazardous Substances Data)

Upstream product

• 76801-85-9 9-Deoxo-9a-aza-9a-homoerythromycin A 
• 92594-46-2 9-deoxo-9a-aza-9a-demethyl-9a-(3-aminopropyl)-9a-homoerythromycin A 
• 139768-71-1 4-benzyloxyphenyl isothiocyanate 
• 92627-70-8 9-deoxo-9a-aza-9a-(β-cyanoethyl)-9a-homoerythromycin A 

Relevant articles and documents

An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics

A series of 15-membered azalide urea and thiourea derivatives has been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive (D6), chloroquine/pyremethamine resistant (W2) and multidrug resistant (TM91C235) strains of Plasmodium falciparum. We have developed an effective automated synthetic strategy for the rapid synthesis of urea/thiourea libraries of a macrolide scaffold. Compounds have been synthesized using a solution phase strategy with overall yields of 50-80%. Most of the synthesized compounds had inhibitory effects. The top 10 compounds were 30-65 times more potent than azithromycin, an azalide with antimalarial activity, against all three strains.