90587-50-1Relevant articles and documents
Hymexazol synthesis method
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Paragraph 0025-0035; 0036-0080, (2017/09/01)
The invention relates to the field of pesticides, and specifically discloses a synthesis method of hymexazol. According to the method, a sodium carbonate-sodium bicarbonate system is adopted to carry out reactions, methyl (ethyl) acetoacetate and hydroxylamine hydrochloride are taken as the raw materials; by dropwise adding sodium hydroxide and methyl (ethyl) acetoacetate, the pH of the condensation reaction system is controlled, through the reaction system, the pH can be stably controlled, after the condensation reactions, the condensation reaction products are slowly dropwise added into preheated concentrated hydrochloric acid to carry out ring-closure reactions; the provided method can obviously reduce the generation of impurities, the yield of hymexazol is increased to 70% or above, and moreover, the synthesis method is environment-friendly and is suitable for industrial production.