90595-67-8Relevant academic research and scientific papers
Synthesis of novel amide-linked dimers of lithocholic acid
Joachimiak, Roman,Piasecka, Monika,Paryzek, Zdzistaw
experimental part, p. 260 - 265 (2009/05/07)
An efficient synthesis of lithocholic amides and amide-linked dimers under mild conditions is described. New σ, m- and p-phenylenediamine-derived dimers of lithocholic acid were synthesised by the activation of the carboxyl group of the bile acid as a mixed anhydride resulting from the reaction of the acid with ethyl chloroformate. The reduction of lithocholic amides afforded the corresponding 24-amino-5β-cholane derivatives. All compounds were characterised by IR, 1H and 13C NMR and mass spectra.
