905953-15-3Relevant academic research and scientific papers
Syntheses of 4-(indole-3-yl)quinazolines - A new class of epidermal growth factor receptor tyrosine kinase inhibitors
Lueth, Anja,Loewe, Werner
, p. 1478 - 1488 (2008)
The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell-surface receptors. The synthesis and pharmacological results of 4-(indole-3-yl)quinazolines are described. The synthesized compounds are new high potent EGFR-tyrosine kinase inhibitors with excellent cytotoxic properties at different cell lines. Furthermore the 4-(indole-3-yl)quinazolines show some tendencies to inhibit the HER-2 TK, too. Moreover this substance class has remarkable strong fluorescence properties.
SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND THEIR USE
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Page/Page column 11; 16-17, (2008/06/13)
The invention relates to the use of substituted 4-(indol-3-yl)quinazolines or one of their salts for inhibiting proteinase activity, in particular the EGF receptor-specific tyrosine protein kinase, for treating tumours, osteoporosis or proliferative epidermal diseases, in addition to novel substituted 4-(indol-3-yl)quinazolines or one of their salts and to a method for producing said substances. The invention also relates to the use of substituted 4-(indol-3- yl)quinazoline derivatives or one of their salts for inhibiting protein kinase activity, in particular for crop protection in the development of fungicidal, herbicidal or insecticidal active ingredients.
