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Downstream Products

• 1013656-30-8 3-[4-(difluoromethoxy)-3-phenoxyphenyl]-1,7-dioxa-2-azaspiro[4.4]non-2-ene 
• 1013656-31-9 3-[4-(difluoromethoxy)-3-(pyridin-4-yloxy)phenyl]-1,7-dioxa-2-azaspiro[4.4]non-2-ene 
• 1013656-22-8 tert-butyl {4-[2-(difluoromethoxy)-5-(1,7-dioxa-2-azaspiro[4.4]non-2-en-3-yl)phenoxy]phenyl}carbamate 

Relevant academic research and scientific papers

INHIBITORS OF PHOSPHODIESTERASE TYPE-IV

The present invention relates to catechol derivatives of formula (I), which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as,

INHIBITORS OF PHOSPHODIESTERASE TYPE-IV

The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.