905986-94-9

Basic information

• Product Name: 1-[(4-Methoxyphenyl)methyl]-4-piperidinone
• Synonyms: 1-(4-Methoxybenzyl)piperidin-4-one90%;1-[(4-Methoxyphenyl)methyl]-4-piperidinone
• CAS NO: 905986-94-9
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.29
• Mol File: 905986-94-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.116g/ml
• CAS DataBase Reference: 1-[(4-Methoxyphenyl)methyl]-4-piperidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-Methoxyphenyl)methyl]-4-piperidinone(905986-94-9)
• EPA Substance Registry System: 1-[(4-Methoxyphenyl)methyl]-4-piperidinone(905986-94-9)

Safety Data

• Hazardous Substances Data: 905986-94-9(Hazardous Substances Data)

Usage

Type of Compound

Piperidinone derivative

Structural Feature

A phenylmethyl group attached to the piperidinone ring

Field of Application

Organic synthesis and pharmaceutical research

Potential Therapeutic Applications

Interaction with biological systems, modulation of enzyme or receptor activities

Building Block

Used for the synthesis of various organic compounds

Applications

Development of new drugs

Interest to Researchers

Medicinal chemistry and drug discovery due to structural complexity and potential bioactivity

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 824-94-2 p-methoxybenzyl chloride 
• 21937-59-7 1-(4-methoxybenzyl)piperidin-4-ol 
• 2393-23-9 4-methoxy-benzylamine 
• 1189373-23-6 C₁₆H₂₃NO₅ 
• 1225937-63-2 C₁₅H₁₉NO₄ 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 802874-67-5 8-(4-methoxybenzyl)-1,4-dioxa-8-azaspiro[4.5]decane 

Downstream Products

• 562824-88-8 N-[1-(4-methoxy-benzyl)-piperidin-4-ylidene]-N'-(2-nitro-phenyl)-hydrazine 
• 1266543-39-8 N-(4-methoxybenzyl)-3,5-bis(4-methylbenzylidene)-4-piperidone 
• 1354566-70-3 N-(4-methoxybenzyl)-3,5-bis(4-chlorobenzylidene)-4-piperidone 
• 1350909-76-0 N-(4-methoxybenzyl)-3,5-bis(benzylidene)-4-piperidone 
• 1354566-67-8 C₂₉H₂₉NO₄ 
• 78471-35-9 1-(4-methoxyphenyl)methyl-4-amino piperidine 
• 1352565-13-9 5-(4-methoxylbenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine 
• 1160755-63-4 4-aminomethyl-1-(4-methoxybenzyl)-piperidin-4-ylamine 

Relevant articles and documents

Highly chemoselective aerobic oxidation of amino alcohols into amino carbonyl compounds

The direct oxidation of unprotected amino alcohols to their corresponding amino carbonyl compounds has often posed serious challenges in organic synthesis and has constrained chemists to adopting an indirect route, such as a protection/deprotection strategy, to attain their goal. Described herein is a highly chemoselective aerobic oxidation of unprotected amino alcohols to their amino carbonyl compounds in which 2-azaadamantane N-oxyl (AZADO)/copper catalysis is used. The catalytic system developed leads to the alcohol-selective oxidation of various unprotected amino alcohols, carrying a primary, secondary, or tertiary amino group, in good to high yield at ambient temperature with exposure to air, thus offering flexibility in the synthesis of nitrogen-containing compounds. Strong as an ox: The highly chemoselective aerobic oxidation of unprotected amino alcohols to their corresponding amino carbonyl compounds has been achieved by using 2-azaadamantane N-oxyl (AZADO)/copper catalysis. This catalytic system oxidizes not only alcohols with tertiary amino groups but also those with secondary and primary amines in good to high yield at ambient temperature in air. bpy=2,2-bipyridyl, DMAP=4-(N,N-dimethylamino)pyridine.

Novel symmetrical trans-bis-Schiff bases of N-substituted-4- piperidones: Synthesis, characterization, and preliminary antileukemia activity mensurations

A series of novel symmetrical trans-bis-Schiff bases (11a, 11b, 11c, 11d, 11e, 11f, 11g, 11h, 11i, 11j, 11k, 11l, 11m) were designed and prepared as novel anticancer analogues, with the trans-configuration confirmed by X-ray diffraction. Preliminary inhibitory effects of these compounds on CML K562 cell growth were investigated, and the potential analogue 11e showed an excellent anti-leukemia activity (IC50=6.35 μg/mL), which is higher than that of the clinical drug 5-fluorouracil (IC50=8.48 μg/mL). Complete assignments had been achieved for the title compounds by spectroscopic techniques, and their structure-activity relationships have been studied.

PESTICIDAL SUBSTITUTED PIPERIDINES

The invention relates to the use of piperidine derivatives encompassed from the general formula (I) for the control of pests, including arthropods and helminths, and a method for the control of pests.