905994-17-4Relevant academic research and scientific papers
Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors
Oertqvist, Pernilla,Peterson, Shane D.,Akerblom, Eva,Gossas, Thomas,Sabnis, Yogesh A.,Fransson, Rebecca,Lindeberg, Gunnar,Helena Danielson,Karlen, Anders,Sandstroem, Anja
, p. 1448 - 1474 (2008/02/13)
Molecular modeling and inhibitory potencies of tetrapeptide protease inhibitors of HCV NS3 proposed phenylglycine as a new promising P2 residue. The results suggest that phenylglycine might be capable of interacting with the NS3 (protease-helicase/NTPase)
Hepatitis C virus inhibitors
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Page/Page column 58, (2008/06/13)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which inhibit the function of the NS3 protease (also referred to herein as “serine protease”) encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS3 protease.
