906012-25-7

Upstream product

• 150986-83-7 2-amino-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid tert-butyl ester 
• 6342-77-4 2-methoxy-benzenepropanoic acid 

Downstream Products

• 1006712-45-3 N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-(2-methoxy-phenyl)-propionamide trifluoroacetate 

Relevant academic research and scientific papers

Novel Tetrahydropyridothiophenes

Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

TETRAHYDROPYRIDOTHIOPHENES AS ANTRIPOLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER

The invention relates to compounds of formula (I) wherein Ra is -C(O)ORI, in which R1 is 1-7C-a.kyl. 3-7C-cycoakyl, 1-7C-alkyl substituted by Raa, or 2-7C-alky substituted by Rab and Rac on different carbon atoms, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and Q is substituted by Rba and Rbb and Rbc, and is phenyl, wich are useful for the therapy of hyperprolif erative diseases, in particular human cancer.