906064-21-9Relevant academic research and scientific papers
Synthesis of 2-substitued 3-aroylindenes via palladium-catalyzed carbonylative cyclization of diethyl 2-(2-(1-alkynyl)phenyl)malonates with aryl halides
Duan, Xin-Hua,Guo, Li-Na,Bi, Hai-Peng,Liu, Xue-Yuan,Liang, Yong-Min
, p. 3053 - 3056 (2006)
The palladium-catalyzed reaction of readily accessible diethyl 2-(2-(1-alkynyl)phenyl)malonates with aryl halides under a balloon pressure of CO produced 2-substitued 3-aroylindenes in good yields. The reaction is believed to proceed via cyclization of th
Synthesis of indenes by the transition metal-mediated carboannulation of alkynes
Zhang, Daohua,Liu, Zhijian,Yum, Eul K.,Larock, Richard C.
, p. 251 - 262 (2007/10/03)
The synthesis of highly substituted indenes has been achieved by three different transition metal-mediated methods. The first method involves the palladium-catalyzed carboannulation of internal alkynes. The second method utilizes a two-step approach, which involves first the palladium/copper- catalyzed cross-coupling of terminal alkynes with appropriately functionalized aryl halides, followed by copper-catalyzed intramolecular cyclization. The third method involves intermolecular palladium-catalyzed arylation of the arylalkynes formed in the first step of the second method.
