906068-68-6

Upstream product

• 882037-00-5 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-trimethylsilanyloxymethyl-biphenyl-4-yl)-amide 
• 754193-45-8 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride 
• 209960-58-7 1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid 
• 367-24-8 4-bromo-2-fluoroaniline 
• 40138-16-7 2-formylbenzene boronic acid 
• 882036-99-9 3-fluoro-2'-trimethylsilanyloxymethyl-biphenyl-4-ylamine 
• 228259-65-2 2-fluoro-4-(2'-hydroxymethylphenyl)aniline 
• 218301-93-0 2-fluoro-4-(2'-formylphenyl)aniline 

Downstream Products

• 882037-20-9 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-piperazin-1-ylmethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole 
• 882037-17-4 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-morpholinomethyl-[1,1']-biphen-4-yl) amiocarbonyl]pyrazole 
• 882037-10-7 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-N-pyrrolidinylmethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole 
• 882037-02-7 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(2'-bromomethyl-3-fluoro-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole 
• 882037-01-6 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole 

Relevant academic research and scientific papers

Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors

We have previously reported on a series of aminobenzisoxazoles as potent, selective, and orally bioavailable factor Xa inhibitors, which culminated in the discovery of razaxaban. Herein, we describe another approach to improve factor Xa inhibitory potency