906079-30-9

Upstream product

• 56305-04-5 trolox 
• 106-28-5 Farnesol 
• 479353-37-2 Acetic acid (S)-6-hydroxy-2-hydroxymethyl-5,7,8-trimethyl-chroman-2-ylmethyl ester 
• 69371-87-5 (S)-(-)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol 
• 105857-77-0 2,2-Bis-hydroxymethyl-5,7,8-trimethyl-chroman-6-ol 
• 100-39-0 benzyl bromide 
• 69427-83-4 (S)-(+)-6-hydroxy-2,5,7,8-tetramethylchroman-2-methanol 
• 906079-26-3 toluene-4-sulfonic acid 6-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5,7,8-trimethyl-chroman-2-ylmethyl ester 
• 906079-24-1 acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5,7,8-trimethyl-chroman-2-ylmethyl ester 
• 906079-25-2 [6-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5,7,8-trimethyl-chroman-2-yl]-methanol 
• 906079-27-4 6-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-2,5,7,8-tetramethyl-chroman 
• 906079-28-5 (S)-[3,4-dihydro-6-benzyloxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl]methyl trifluoromethane-sulfonate 
• 56881-53-9 (E,E)-farnesyl phenylsulfone 
• 53101-51-2 (-)-6-benzyloxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 

Downstream Products

• 1721-51-3 alpha-tocotrienol 
• 906079-31-0 (R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane 

Relevant academic research and scientific papers

CHINONE-, HYDROCHINOME- AND NAPHTHOCHINONE-ANALOGUES OF VATIQUIONE FOR TREATMENT OF MITOCHONDRIAL DISORDER DISEASES

The disclosure provides therapeutic compositions (i.e., therapeutic agents) and methods of preventing or treating Friedreich's ataxia in a mammalian subject, reducing risk factors, signs and/or symptoms associated with Friedreich's ataxia (e.g. Complex I deficiency), and/or reducing the likelihood or severity of Friedreich's ataxia. The disclosure further provides novel intermediates for the production of said therapeutic compositions and related reduced versions of said therapeutic compositions, which reduce forms may also be used as therapeutic agents (or prodrugs of the therapeutic agent(s)).

Chemoenzymatic synthesis of both enantiomers of α-tocotrienol

The stereoselective acylation of the achiral chromanedimethanol derivative 1 by vinyl acetate in the presence of Candida antarctica lipase B gave the (S)-monoester 2 in high enantiomeric purity (ee ≥ 98%). Enzymatic hydrolysis of diesters of compound 1 failed to give (R)-monoester 2 in good yield and high ee. Thus, both enantiomers of α-tocotrienol were synthesized from the (S)-monoester 2.