906081-33-2Relevant articles and documents
Identification of metabolites of the tryptase inhibitor CRA-9249: Observation of a metabolite derived from an unexpected hydroxylation pathway
Yu, Walter,Dener, Jeffrey M.,Dickman, Daniel A.,Grothaus, Paul,Ling, Yun,Liu, Liang,Havel, Chris,Malesky, Kimberly,Mahajan, Tania,O'Brian, Colin,Shelton, Emma J.,Sperandio, David,Tong, Zhiwei,Yee, Robert,Mordenti, Joyce J.
, p. 4053 - 4058 (2007/10/03)
The metabolites of the tryptase inhibitor CRA-9249 were identified after exposure to liver microsomes. CRA-9249 was found to be degraded rapidly in liver microsomes from rabbit, dog, cynomolgus monkey, and human, and less rapidly in microsomes from rat. T