906096-16-0Relevant academic research and scientific papers
Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities
Abou El Ella, Dalal A.,Ghorab, Mostafa M.,Noaman, Eman,Heiba, Helmy I.,Khalil, Amira I.
, p. 2391 - 2402 (2008/09/21)
Novel pyrrolo[2,3-d]pyrimidine derivatives 4a-e, 10, 14, 15, pyrazolopyrrolopyrimidine 13, pyrrolotriazolopyrimidine 5-9, 17 and pyrrolopyrimidotriazine 18 are reported herein. The design of these compounds was based upon the molecular modeling simulation
Novel antitumor and radioprotective sulfonamides containing pyrrolo[2,3-d]pyrimidines
Ghorab, Moustafa M.,Noaman, Eman,Ismail, Magda M. F.,Heiba, Helmy I.,Ammar, Yousry A.,Sayed, Marwa Y.
, p. 405 - 413 (2007/10/03)
Several sulfonamides having pyrrole (5a-c, 8, 11b-19, 23, 24), pyrrolo[2,3-d] pyrimidine (6, 7, 10, 20, 21, 25) and pyrrolo[2,3-b]pyridine (22) were synthesized and evaluated for their antitumor and radioprotective activities. The structure of the synthes
Novel synthesis of pyrrolo[2,3-d] pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents
Ismail, Magda M. F.,Ghorab, Mostafa M.,Noaman, Eman,Ammar, Yousry A.,Heiba, Helmy I.,Sayed, Marwa Y.
, p. 301 - 308 (2007/10/03)
A novel series of pyrrolo[2,3-d] pyrimidines bearing sulfonamide moieties have been synthesized and tested for their antitumor activity. Among them, compounds 4, 8b, 8d, 8g and 14 showed promising antitumor activity. Moreover, compound 8d exhibited radiop
