906352-14-5Relevant academic research and scientific papers
Preparation of N-aryl-substituted spiro-β-lactams via staudinger cycloaddition
Barba, Victor,Hernandez, Cecilia,Rojas-Lima, Susana,Farfan, Norberto,Santillan, Rosa
, p. 2025 - 2032 (1999)
The interest in the study of β-lactams continues due to their therapeutic importance as antibiotics. In this work, six spiro-β-lactams (7a-7c, 8a-8c) have been prepared using the [2+2] cycloaddition of isomaleimides to acid chlorides. The heterobicyclic structures obtained have been characterized by mass spectrometry, IR, NMR spectroscopy, and for compounds 7a, 7b, and 8b the X-ray crystallographic study showed a nearly planar arrangement for the β-lactam ring.
