906361-91-9Relevant academic research and scientific papers
Synthesis and photophysical properties of 2-aryl-5-carbonyl indolizines
Arroio, Thais R.,Berlim, Leonardo S.,Bertallo, Camila R. S.,Clososki, Giuliano C.,Ito, Amando S.,Olivier, Danilo S.
, (2021/12/09)
Herein we reported the synthesis of 20 novel fluorescent 5-carbonylated 2-arylindolizines derivatives through the reaction between organolithium intermediates with different electrophiles. To investigate the effects of the substituents on the wavelengths
An improved synthesis of some 5-substituted indolizines using regiospecific lithiation
Kuznetsov, Alexey G.,Bush, Alexander A.,Rybakov, Viktor B.,Babaev, Eugene V.
, p. 1074 - 1083 (2007/10/03)
Various 2-substituted indolizines can be directly and selectively lithiated in the 5 position and subsequent reactions with different electrophiles lead to some novel classes of indolizines. In particular, previously unknown 5-formyl- and 5-iodoindolizine have been prepared by this way and the molecular structure of 5-formyl-2-phenylindolizine was confirmed by X-Ray analysis. The reactivity of the 5-CHO- and 5-COPh groups toward some nucleophiles has been examined, and some additional classes of derivatives (oximes and alcohols) have been obtained. The possibility of Suzuki cross-coupling of 5-iodoindolizines and boronic acids was proven.
