906370-48-7Relevant academic research and scientific papers
Expeditious synthesis of 2-aryl substituted imidazolines and imidazoles
Lauwagie, Sylvia,Millet, Regis,Pommery, Jean,Depreux, Patrick,Henichart, Jean-Pierre
, p. 1149 - 1162 (2007/10/03)
A versatile and efficient method for the synthesis of 2-aryl substituted imidazolines and imidazoles bearing a carboxylate group on C-4 is reported. Three different synthetic pathways were explored, compared and optimized. The selected procedure involves condensation of methyl 2,3-diaminopropionate with different imino ethers. The ring closure, monitored by LC-MS analysis, was facilitated by heating at reflux in ethanol leading to increase the rate of cyclization.
