906375-47-1

Upstream product

• 906375-46-0 (2S,4R)-4-(3-Benzyloxy-propoxy)-1-[(S)-2-cyclohexyl-2-(4-nitro-phenoxycarbonylamino)-acetyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 214424-24-5 N-(3-benzyloxybenzyl)methylamine 

Downstream Products

• 906375-52-8 (7R,9S,12S)-12-Cyclohexyl-15-methyl-11,14-dioxo-2,6-dioxa-10,13,15-triaza-tricyclo[15.3.1.1^7,10]docosa-1⁽²¹⁾,17,19-triene-9-carboxylic acid 
• 906375-49-3 (7R,9S,12S)-12-Cyclohexyl-15-methyl-11,14-dioxo-2,6-dioxa-10,13,15-triaza-tricyclo[15.3.1.1^7,10]docosa-1⁽²¹⁾,17,19-triene-9-carboxylic acid methyl ester 

Relevant academic research and scientific papers

P2-P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.