90641-17-1

Upstream product

• 84230-76-2 trans-1-Phenylsulfinylmethyl-1,3-butadiene 
• 87413-21-6 (4S,4aS,5S,6S,7aS)-6-Ethyl-5-hydroxy-2,2,4a,5-tetramethyl-tetrahydro-furo[2,3-d][1,3]dioxine-4-carbaldehyde 
• 931-59-9 benzenesulfenyl chloride 
• 87413-15-8 3-Chloro-benzoic acid (1R,3R,4S,5S,6R)-6-(2-benzyloxy-ethyl)-4-hydroxy-4,5-dimethyl-2,7-dioxa-bicyclo[3.2.0]hept-3-yl ester 
• 87413-17-0 (4R,4aS,5S,6S,7aS)-4-(2-Benzyloxy-ethyl)-6-ethyl-2,2,4a,5-tetramethyl-tetrahydro-furo[2,3-d][1,3]dioxin-5-ol 
• 87413-14-7 (1S,5R,6R)-6-(2-Benzyloxy-ethyl)-4,5-dimethyl-2,7-dioxa-bicyclo[3.2.0]hept-3-ene 
• 87413-20-5 (4R,4aS,5S,6S,7aS)-6-Ethyl-2,2,4a,5-tetramethyl-4-vinyl-tetrahydro-furo[2,3-d][1,3]dioxin-5-ol 
• 87413-18-1 (4R,4aS,5S,6S,7aS)-6-Ethyl-4-(2-hydroxy-ethyl)-2,2,4a,5-tetramethyl-tetrahydro-furo[2,3-d][1,3]dioxin-5-ol 
• 922-65-6 divinylcarbinol 
• 20843-07-6 3,4-dimethylfuran 

Downstream Products

• 90623-38-4 4(R,S),6(R,S)-dihydroxy-5(R,S),6-dimethyl-7(R,S)-ethyl-(3(R,S)(5-phenylsulfinyl)-(E,E)-penta-1,3-dien-1-yl)-1(S,R)-2,8-dioxabicyclo<3.3.0>octane 
• 79663-49-3 (+/-)-asteltoxin 

Relevant academic research and scientific papers

Total synthesis of (±)-asteltoxin

A convergent synthesis of (±)-asteltoxin has been achieved in 16 steps (3.0% overall yield) from 3,4-dimethylfuran. The attachment of the triene pyrone side chain to the bis(tetrahydrofuran) skeleton proceeds by way of the addition of the Corey equivalent to anion 3 to the aldehyde 2 and a subsequent aldol condensation-dehydration reaction of pyrone 4.