90645-84-4Relevant articles and documents
FUSED 6,5 BICYCLIC RING SYSTEM P2 LIGANDS, AND METHODS FOR TREATING HIV
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Page/Page column 32; 43, (2012/07/14)
Inhibitors of HIV-1 protease and compositions containing them are described. Use of the inhibitors and compositions containing them to treat HIV, AIDS, and AIDS-related diseases is described.
Photochemical and photophysical studies of bicyclo[4.3.0]non-1(6)-en-2-one
Schuster, David I.,Woning, Jan,Kaprinidis, Nikolas A.,Pan, Yanping,Cai, Bing,Barra,Rhodes, Christopher A.
, p. 7029 - 7034 (2007/10/02)
The properties of the lowest excited triplet state of bicyclo[4.3.0]non-1 (6)-en-2-one (BNEN) have been investigated by nanosecond transient absorption spectroscopy, photoacoustic calorimetry, measurements of 1O2 quantum yields, and photochemical studies in solution. Both the lifetime (1.4 μs) and the energy (74-76 kcal mol-1) of the BNEN triplet reflect its exceptional conformational rigidity, which prohibits relaxation along the 3(π,π*) potential energy surface by twisting around the C=C bond. Fumaro- and maleonitrile quench the BNEN triplet at a diffusion-controlled rate by triplet energy transfer. This process leads to cis-trans isomerization of the alkenes. The BNEN triplet displays extensive self-quenching with ksq = 2.6 × 107 M-1 s-1. This process involves intermolecular H-abstraction, but formation of dimeric triplet 1,4-biradicals cannot be excluded. The product of the former is a radical (3) with a lifetime of 4.1 μs. Its transient absorption spectrum (λmax 299 nm) is hypsochromically shifted with respect to that of the BNEN triplet (λmax 311 nm). The solvent effects on the photophysical properties suggest that the T1 state of BNEN is a (π,π*) state in acetonitrile and an (n,π*) state in benzene. The BNEN triplet undergoes neither [2 + 2] cycloaddition reactions with itself, cyclopentene, fumaronitrile, or maleonitrile nor the lumiketone rearrangement, but readily abstracts H-atoms from itself, cyclopentene, and 2-propanol.
STEREOSELECTIVITE DE L'ADDITION DE REACTIFS NUCLEOPHILES SUR DES CETONES POLYCYCLIQUES A JONCTION TRANS
Calmes, D.,Gorrichon-Guigon, L.,Maroni, P.,Accary, A.,Barret, R.,Huet, J.
, p. 879 - 885 (2007/10/02)
The nucleophilic additions of hindered organometallic compounds to polycyclic ketones with trans ring junctions involve predominant axial attack when flattening of the ring containing the carbonyl group occurs.The influence of nucleophile structure (O-Por C-metalled character) on equatorial or axial attack is discussed.
