906465-09-6Relevant articles and documents
Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury
Kalai, Tamas,Khan, Mahmood,Balog, Maria,Kutala, Vijay Kumar,Kuppusamy, Periannan,Hideg, Kalman
, p. 5510 - 5516 (2007/10/03)
Trimetazidine, the known anti-anginal and anti-ischemic drug, was modified by pyrroline and tetrahydropyridine nitroxides and their hydroxylamine and sterically hindered secondary amine precursors. The synthesized new compounds proved to be better superox