90648-03-6Relevant academic research and scientific papers
Potential mechanism-based tyrosine kinase inhibitors. Part 1. Phosphorylation chemistry of pyridine N-oxides
Andrews, David M.,Page, Timothy C. M.,Peach, Josephine M.,Pratt, Andrew J.
, p. 1045 - 1048 (2007/10/02)
Phosphorylated derivatives of 4-picoline N-oxide have been observed on treatment with both phosphorylating and phosphitylating agents.These intermediates were trapped by external nucleophiles.Propane-1-thiol reacted preferentially at carbon to yield a propylsulfanylpyridine whereas propylamine reacted preferentially at phosphorus.This chemistry carries implications for the design of mechanism-based tyrosine kinase inhibitors.
