906483-36-1Relevant articles and documents
Novel method for synthesizing ioxilan
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Paragraph 0047; 0057; 0062; 0067; 0072; 0077; 0082; 0087, (2018/03/01)
The invention belongs to the technical field of preparation of a non-ionic X-ray contrast agent and discloses a novel method for synthesizing ioxilan. The novel method for synthesizing ioxilan comprises the step of performing reactions such as acetic anhydride protection, ester exchange, iodination and alkylation to obtain ioxilan by taking 5-amino-N-(2-hydroxyl ethyl)-m-formamide methyl benzoate as a raw material. The invention provides an improved ioxilan synthetic method and a process easy for industrialized purification and solvent recrystallization. The invention provides the ioxilan synthesizing method which is more environment-friendly, cheap, high in yield and high in purity by taking 5-amino-N-(2-hydroxyl ethyl)-m-formamide methyl benzoate as the raw material.