90653-47-7

Basic information

• Product Name: L-Prolinamide, 3-[(1,1-dimethylethoxy)methyl]-N-[(phenylmethoxy)carbonyl]-L-histidyl-
• CAS NO: 90653-47-7
• Molecular Formula: C24H33N5O5
• Molecular Weight: 471.557
• Mol File: 90653-47-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Prolinamide, 3-[(1,1-dimethylethoxy)methyl]-N-[(phenylmethoxy)carbonyl]-L-histidyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Prolinamide, 3-[(1,1-dimethylethoxy)methyl]-N-[(phenylmethoxy)carbonyl]-L-histidyl-(90653-47-7)
• EPA Substance Registry System: L-Prolinamide, 3-[(1,1-dimethylethoxy)methyl]-N-[(phenylmethoxy)carbonyl]-L-histidyl-(90653-47-7)

Safety Data

• Hazardous Substances Data: 90653-47-7(Hazardous Substances Data)

Upstream product

• 90653-44-4 N(α)-benzyloxycarbonyl-N(?)-t-butoxymethyl-L-histidine 
• 7531-52-4 L-prolinamide 
• 15545-10-5 Z-His-OMe 
• 90653-42-2 N(α)-benzyloxycarbonyl-N(τ)-tert-butyloxycarbonyl-L-histidine methyl ester 
• 90653-43-3 N(α)-benzyloxycarbonyl-N(?)-t-butoxymethyl-L-histidine methyl ester 
• 40556-01-2 tert-butyl chloromethyl ether 

Downstream Products

• 24305-27-9 L-pyroglutamyl-L-histidyl-L-proline amide 

Relevant articles and documents

Acid-labile Histidine Side-chain Protection: the N(?)-t-Butoxymethyl Group

N(α)-Benzyloxycarbonyl-N(?)-t-butoxymethyl-L-histidine (1) and N(α)-fluoren-9-ylmethoxycarbonyl-N(?)-t-butoxymethyl-L-histidine (2) have been prepared and their use for the synthesis of peptides containing histidine residues has been demonstrated in two simple exercises; no difficulties were encountered, the base- and hydrogenolysis-resistant imidazole protecting group ultimately being removed by mild acidolysis.