906532-69-2Relevant academic research and scientific papers
Efficient access to cyclic ureas via Pd-catalyzed cyclization
McLaughlin, Mark,Palucki, Michael,Davies, Ian W.
, p. 3311 - 3314 (2007/10/03)
An efficient regioselective method for the preparation of structurally diverse imidazopyridinones and benzoimidazolones starting from readily available and economical starting materials is described. High-yielding reductive alkylation of electron-deficient o-haloarylamines followed by treatment with inexpensive N-chlorosulfonyl isocyanate afforded primary ureas in good overall yields. A Pd-catalyzed urea cyclization reaction furnished imidazopyridinones and benzoimidazolones in excellent yields. Overall, the developed chemistry provides rapid access to pharmaceutically important heterocyclic compounds with high efficiency.
